Howard University National human Genome Center
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Why the Human Genome Center at Howard University?

The Issues 

The emergence of the Human Genome Project at this juncture in the evolution of western science is not only impacting the way "we view" biology, but also how "we do" biology. The cooperation and collective skills of large coalitions of laboratory scientists, community-oriented biomedical research investigators, community advocates, and an informed population are some of the participants increasingly required to conduct genome science in medicine. These "mega" collaborative research teams are often needed in connecting the multiple levels of genome science and society. The Human Genome Project is unique among the hard sciences in having as part of its initial core, a component to anticipate and address ethical, legal, and social issues emanating from the advancement of knowledge gained from the science. Because of inherent variation in the genome, this project, perhaps like no other leading edge of western science, challenges science to expand, (i.e., make more inclusive) the context or measure of humanity, in order to better understand the content, (i.e., genome and inner dimensions) of human biology and molecular medicine.  

The goal of the NHGC at HU is to bring multicultural perspectives and resources to an understanding of human genome variation and its implications for human health. The fulfillment of this goal is a scientific imperative, if the human genome project is to now shift from the success of sequencing the three billion nucleotides in the human genome to the significance of applying the knowledge gained towards eliminating health disparities among different ethnic groups in the promotion of health and prevention of disease. As the Human Genome Project progresses from structural to functional genomics, the absolute importance of population variability in the genetic diagnosis, treatment and management of complex diseases cannot be marginalized or ignored. Among this nation's academic centers, Howard University is uniquely poised and prepared by virtue of its identity, history, and purpose, to provide leadership for America and the global community in addressing the array of very challenging biological, ethical, legal, and social issues introduced at this time by the emergence of the Human Genome Project.  

The Challenges 

Parallels can be made between social conditions and scientific thought in the mid 19th century that provided the context for chartering a Howard University to meet growing national needs to educate, train, and incorporate millions of newly emancipated slaves into the mainstream of American life and culture, and today’s need to bring millions of African Americans and other historically disenfranchised people of color into the mainstream of genomic medicine, the leading edge of 21st century biomedical science and thought. Likewise, the establishment of the National Human Genome Center at Howard University is in many respects part of Howard ’s charter and historic mission as a forum for addressing the national need for mass education and training to meet the multidimensional ethical, legal, and social challenges of gross disparities in the health, education and participation of historically disenfranchised groups in the benefits of an educated and informed democratic society. 

Howard University was chartered in 1867 by an Act of Congress to educate youth in the liberal arts and sciences and other departments. In 1879, Congress approved a special appropriation for the University and in 1928 amended the charter to authorize an annual federal appropriation for construction, development, improvement and maintenance of the University. In one hundred and thirty-three years of service to its constituents, Howard University has graduated this nation's largest number of African American scholars and professionals in the Arts and Sciences. Included among its distinguished alumni are educators, doctors, dentists, architects, lawyers, engineers, scientists, and administrators. The University's motto "Truth and Service", has fostered an environment of intellectual fervor and courageous leadership that under girds Howard's traditions. Howard is indeed the world's largest and most comprehensive university with a predominantly African-American enrollment and faculty. Howard University is only HBCU in the nation classified as a Doctoral/Research University-Extensive by the Carnegie Foundation for the Advancement of Teaching. Howard is not only a national university, but also an international university, with a global perspective on the major issues and challenges facing this nation and the global community. As articulated in the Vision Statement – Howard University is a comprehensive research university, unique and irreplaceable, defined by its core values, the excellence of all its activities --- instruction, research and service- and by its enduring commitment to educating youth, African Americans and other people of color in particular, for leadership and service to our nation and the world. Howard University is dedicated to attracting, sustaining, and developing a cadre of faculty who, through their teaching and research, are committed to producing distinguished and compassionate graduates who seek solutions to human and social problems in the United States and throughout the world. Howard University is fully accredited with several undergraduate and graduate programs in Medicine, Pharmacy, Dentistry, Nursing, Engineering, Law, Education, and others. The rich history of Howard University, its unquestionable commitment to the well-being and training of African Americans and other people of color provide the foundation and framework for the NHGC. As an academic center of African American thought, critical analysis and leadership, investigators at the NHGC will enhance Howard’s legacy of leadership for America by systematically pursuing the goals and objectives of the NHGC and introducing new perspectives on the generation as well as the interpretation and implications of knowledge gained from this rapidly changing arena of investigation.

The Opportunities 

Decoding the human genome will lead to new ways to prevent, diagnose, treat, and cure disease. With a focus on the genetics of diseases common in African Americans, the NHGC will provide unique and challenging insights into the relevance of genome variation to population-based differences in disease susceptibility and/or resistance. Alterations in our genes are responsible for an estimated 5000 clearly hereditary diseases, such as Huntington’s disease, cystic